Dataset overview

Number of columns (total): 16

Number of rows (total): 1030

Number of unique IDs: 64

Number of observations per IDs: mean 16.09 , median 14 , min 14 , max 26

Error checking

This section checks for unexpected missing or erroneous values in the dataset, such as: NAs, empty cells, periods cells (cells that contain only period) and character values. Please inspect the tables below.

1. There are no unexpected NAs

Dataset contains no NAs


2. There are no unexpected empy cells

Dataset contains no empty cells


3. There are no unexpected periods cells

Dataset contains no periods cells

4. There are no unexpected character values
Character values were found in these columns: ID, TIME, AMT, DV, DVID, EVID, WT, AGE, SEX, STUDY, ECOG_STATUS, ECOG_STATUS_NEW, VCOR_GENOTYPE, CLCR, MDV, CMT
Count Fraction
DVID 1030 1
SEX 1030 1
STUDY 1030 1
VCOR_GENOTYPE 1030 1
Character values
Column value IDs
DVID cp 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66
DVID pca 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66
SEX female 5, 7, 9, 15, 16, 38, 40, 42, 48, 49
SEX male 1, 2, 3, 4, 6, 8, 10, 12, 13, 14, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 39, 41, 43, 45, 46, 47, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66
STUDY STD_1 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33
STUDY STD_2 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66
VCOR_GENOTYPE AA 3, 4, 9, 19, 20, 21, 22, 23, 24, 29, 33, 36, 37, 39, 42, 46, 51, 52, 53, 54, 57
VCOR_GENOTYPE AG 1, 5, 6, 7, 10, 12, 13, 14, 15, 17, 18, 25, 26, 27, 28, 32, 34, 49, 62, 66
VCOR_GENOTYPE GG 2, 8, 16, 30, 31, 35, 38, 40, 41, 43, 45, 47, 48, 50, 55, 56, 58, 59, 60, 61, 63, 64, 65

Dates and times

5. All dates are in the expected formats

No date column provided

Covariates

Covariates specified by user: WT, CLCR, AGE, SEX, STUDY, ECOG_STATUS, VCOR_GENOTYPE

6. All time-invariant covariates are expected to be time-invariant

Covariates identified to be time-invariant: WT, CLCR, AGE, SEX, STUDY, VCOR_GENOTYPE

7. All time-varying covariates are expected to be time-varying

Covariates identified to be time-varying: ECOG_STATUS

There are no covariates with NAs / empty cells / period cells / unexpected character values in the dataset .

Time-varying covariates

Here are spaghetti plots for the covariates that were identified identified to be time-varying.

8. All time-varying covariates change over time as expected


Categorial covariates

Covariates specified as categorical: SEX , STUDY , ECOG_STATUS , VCOR_GENOTYPE

9. All categorical covariates have the expected levels
IDs with value
Records per ID
SEX N fraction N fraction
female 10 0.16 20.20 1
male 54 0.84 15.33 1
IDs with value
Records per ID
STUDY N fraction N fraction
STD_1 32 0.5 16.09 1
STD_2 32 0.5 16.09 1
IDs with value
Records per ID
ECOG_STATUS N fraction N fraction
0 20 0.31 14.35 0.95
1 22 0.34 14.64 0.90
2 29 0.45 14.52 0.86
IDs with value
Records per ID
VCOR_GENOTYPE N fraction N fraction
AA 21 0.33 16.29 1
AG 20 0.31 16.20 1
GG 23 0.36 15.83 1

Numerical covariates

Covariates specified as continuous: WT , CLCR , AGE

10. All numerical covariates have the expected distributions
■ - possible outliers

Dependent variable

11. Dependent variable have the expected distribution

❗ There are negative values of dependent variable detected!

Dependent variable statistics (by provided DV-grouping indicators):

DVID STUDY Mean Median Min Max SD Q0.25 Q0.75
cp STD_1 6.41 6.10 0.00 17.60 3.82 3.20 8.90
cp STD_2 6.46 6.06 -2.83 21.48 4.75 2.98 9.79
pca STD_1 37.50 28.00 9.00 100.00 26.06 20.00 42.00
pca STD_2 37.47 27.86 8.64 107.05 26.22 20.01 41.66


- possible outliers
12. Dependent variable change over time as expected

Special columns

Special columns specified by user: DVID , EVID , AMT , CMT , MDV

13. All special columns have the expected values and counts
IDs with value
Records per ID
DVID N fraction N fraction
1 64 1 8.84 0.54
2 64 1 7.25 0.46
IDs with value
Records per ID
EVID N fraction N fraction
0 64 1 15.09 0.94
1 64 1 1.00 0.06
IDs with value
Records per ID
MDV N fraction N fraction
0 64 1 15.09 0.94
1 64 1 1.00 0.06
IDs with value
Records per ID
CMT N fraction N fraction
1 64 1.0 1.00 0.06
2 32 0.5 15.09 0.94
4 32 0.5 15.09 0.94
14. There are no unexpected dosages and all dosages are in the consistent dimensionality
AMT information
Summary
IDs with value
Records per ID
AMT N fraction N fraction
AMT = 0 or “.” 64 1 15.09 0.94
AMT > 0 64 1 1.00 0.06

For non-zero AMT values:

Mean Median Min Max SD Q0.25 Q0.75
152.5 176.5 60 200 49.7 108.75 200


Check the histogram for multimodalities, that may indicate the presence of different dimensionalities.

Detailed
IDs with value
Records per ID
AMT N fraction N fraction
0.0 64 1.00 15.09 0.94
60.0 1 0.02 1.00 0.05
75.0 2 0.03 1.00 0.04
85.0 1 0.02 1.00 0.05
87.0 2 0.03 1.00 0.07
88.5 1 0.02 1.00 0.07
90.0 1 0.02 1.00 0.06
93.0 2 0.03 1.00 0.07
95.5 1 0.02 1.00 0.07
100.0 3 0.05 1.00 0.06
105.0 2 0.03 1.00 0.07
110.0 1 0.02 1.00 0.07
112.0 2 0.03 1.00 0.07
113.0 3 0.05 1.00 0.06
115.0 1 0.02 1.00 0.07
117.0 1 0.02 1.00 0.07
120.0 4 0.06 1.00 0.07
123.0 1 0.02 1.00 0.05
125.0 1 0.02 1.00 0.07
135.0 1 0.02 1.00 0.05
153.0 1 0.02 1.00 0.07
200.0 32 0.50 1.00 0.06


15. There are no records with impossible combination of special columns values

EVID = 0 EVID = 1
DVID = 1 7.84 1
DVID = 2 7.25 0
CMT = 1 CMT = 2 CMT = 4
DVID = 1 1 3.92 3.92
DVID = 2 0 3.62 3.62
MDV = 0 MDV = 1
DVID = 1 7.84 1
DVID = 2 7.25 0
CMT = 1 CMT = 2 CMT = 4
EVID = 0 0 7.55 7.55
EVID = 1 1 0.00 0.00
MDV = 0 MDV = 1
EVID = 0 15.09 0
EVID = 1 0.00 1
MDV = 0 MDV = 1
CMT = 1 0.00 1
CMT = 2 7.55 0
CMT = 4 7.55 0

DVID = 1 DVID = 2
AMT = 0 or “.” 502 464
AMT > 0 64 0
EVID = 0 EVID = 1
AMT = 0 or “.” 966 0
AMT > 0 0 64
CMT = 1 CMT = 2 CMT = 4
AMT = 0 or “.” 0 483 483
AMT > 0 64 0 0
MDV = 0 MDV = 1
AMT = 0 or “.” 966 0
AMT > 0 0 64




Produced by Phandorin (v. 0.0.2)

QC summary

Error checking

  1. There are no unexpected NAs

  2. There are no unexpected empty cells

  3. There are no unexpected periods cells

  4. There are no unexpected character values

Dates and times

  1. All dates are in the expected formats

Covariates

  1. All time-invariant covariates are expected to be time-invariant

  2. All time-varying covariates are expected to be time-varying

  3. All time-varying covariates change over time as expected

  4. All categorical covariates have the expected levels

  5. All numerical covariates have the expected distributions

Dependent variable

  1. Dependent variable have the expected distribution

  2. Dependent variable change over time as expected

NONMEM-specific columns

  1. All special columns have the expected values and counts

  2. There are no unexpected dosages and all dosages are in the consistent dimensionality

  3. There are no records with impossible combination of special columns values